Medical Weight Loss
Tirzepatide, dual receptor, weekly.
Tirzepatide in Raleigh NC is a weekly dual GIP / GLP-1 receptor agonist injection used for medical weight loss. In head-to-head trials, tirzepatide produced greater weight reduction than semaglutide on average (approximately 15 to 20 percent vs. 10 to 15 percent at maintenance). At La Miel Aesthetics, tirzepatide is dispensed only after physician medical screening, with structured titration and monthly follow-up.
- Physician-supervised
- Compounded by licensed pharmacy
- Monthly follow-up
- Greater average weight loss vs. semaglutide
- Bilingual care
Clinically reviewed by Dr. Susan Lovelle, MD, Medical Director, La Miel Aesthetics. Adriana Sandoval Veliz, RN, MSN, contributed clinical input. Last reviewed: .
What this is
What tirzepatide does and why dual receptor matters
Tirzepatide activates two gut-hormone pathways at once: GLP-1 (the same target as semaglutide) and GIP (glucose-dependent insulinotropic polypeptide). The dual action produces stronger appetite suppression, better glycemic control, and on average greater weight reduction than GLP-1 agonism alone.
In the SURMOUNT-1 trial, tirzepatide at maximum dose produced approximately 22 percent average body weight reduction over 72 weeks. Semaglutide in comparable trials produced approximately 15 percent. Individual response varies, and not every patient tolerates the higher dose.
Tirzepatide is not categorically better for every patient. Some patients have side-effect profiles that favor semaglutide. Some do not tolerate the GIP component. We choose based on history, goals, and response.
At La Miel
Our tirzepatide protocol
Same protocol skeleton as semaglutide: physician intake, structured titration, monthly follow-up, clear discontinuation criteria.
Medical intake and contraindication screening
Identical to semaglutide screening: medullary thyroid carcinoma history (personal or family), MEN2 syndrome, pancreatitis history, severe GI disease, pregnancy, and other contraindications are screened.
Suited for: Patients with BMI 27+ with weight-related comorbidities, or BMI 30+ without.
Titration schedule
Standard titration: 2.5 mg weekly for 4 weeks, then 5 mg, 7.5 mg, 10 mg, 12.5 mg, and (when needed) 15 mg. Slow titration minimizes GI side effects.
Suited for: All starting patients. Many pause at 7.5 or 10 mg when results plateau at acceptable level.
Monthly follow-up
Same as semaglutide: weight, side effects, dose decision, lab work as indicated.
Suited for: All active patients.
Discontinuation criteria
Same as semaglutide: severe persistent nausea, pancreatitis signs, gallbladder disease, suicidal ideation, or pregnancy mandates discontinuation.
Suited for: Patient safety is non-negotiable.
Ready to start?
A consultation tells us what your skin needs. It takes under an hour.
What to expect
What to expect
Intake visit
45 to 60 minutes. Medical history, contraindication screening, goals discussion, consent.
First injection
Walked through in clinic. We teach injection technique and side-effect management.
First 4 weeks
Starting dose 2.5 mg. Nausea is the most common side effect.
Months 2 to 6
Monthly titration. Many patients reach 7.5 to 10 mg maintenance with strong results by month 5 to 6.
Long-term
Monthly to quarterly check-ins at maintenance. We discuss whether to continue, step down, or pause based on your goals.
Pricing
A note on pricing
Compounded tirzepatide pricing varies by dose and pharmacy. We provide a clear monthly cost estimate at intake. Brand-name Mounjaro / Zepbound through insurance is also an option; some patients pursue that route with their primary care provider. Financing available.
Common questions
Common questions about tirzepatide
Tirzepatide activates both GLP-1 and GIP receptors, producing greater average weight loss than semaglutide which only activates GLP-1. Tirzepatide is a dual receptor agonist activating both GLP-1 and GIP, while semaglutide activates only GLP-1. The dual mechanism produces greater average weight loss in trials (approximately 15 to 20 percent vs. 10 to 15 percent at maintenance). Side-effect profiles are similar though tirzepatide can produce more pronounced GI effects in some patients.
Keep exploring
Related on La Miel
Ready to book Tirzepatide?
Tell us what you would like to address. A consultation maps the right plan, the right product, and the right sequence for your skin.
Ready When You Are
Two ways to start: book the specific treatment you came for, or book a consultation and we will build your plan together.
Mon 10 to 8, Wed to Fri 10 to 5, Sat 9 to 2. Closed Tue and Sun.
7718 Six Forks Road, Suite 106, Raleigh, NC 27615